Targeted Mutation Screening

Viafet's Targeted Mutation Screening completed with a technique called Sanger Sequencing is a diagnostic tool completed through blood test that identifies the mutated gene or genes causing a genetic disease in your family. The identification of a gene mutation(s) allows for further steps to be taken to prevent the passing on of the condition to future generations and may aid in the improvement of treatment of an affected individual. In most cases, after identifying the cause of genetic disease through Targeted Mutation Screening, couples choose to complete an IVF cycle with a Pre-Implantation Genetic Diagnosis (PGD) for Single Gene Disorders, a genetic test that allows for your embryos to be screened for the genetic disease affecting your family, before pregnancy. With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients.

Is Targeted Mutation Screening right for me?

Viafet's Targeted Mutation Screening through Sanger Sequencing is the most efficient test to identify the genetic cause of disease or disabilities in your family in the following circumstances:

  1. The genetic condition affect your family or for which you would like to be screened is known to be caused by a few number of mutations. Examples include Sickle Cell Anemia, Spinal Muscular Atrophy, Sanjad Sakati and more.
  2. You have the genetic report of a family member and would like to be screened for the same mutation.
  3. The gene causing the genetic condition affecting your family is of small size (less than 5 exons). Examples include Beta Thalassemia, Connexin 26 (hearing loss) and more.

If you or a family member are suffering from a genetic condition and the above statements do not describe your situation, Whole Exome Sequencing may an option for you.

Viafet's team of genetic counselors are available to help you determine what best test for you and your family. Contact Viafet today to share any previous medical or genetic reports and have your questions answered.

How does Targeted Mutation Screening work?

Viafet completes Targeted Mutation Screening through blood sample utilizing a method of DNA sequencing called Sanger Sequencing. Sanger Sequencing allows for the identification of gene mutation in very specific locations of genetic material. DNA material is amplified, sequenced and analyzed using a fully automated Sanger Sequencing machine.

Sanger Sequencing was the most widely used sequencing method for approximately 25 years until the recent development of a technique called Next Generation Sequencing . For certain types of mutation screening, primarily smaller-scaled sequencing of targeted mutations, Sanger Sequencing remains the key standard. Sanger Sequencing is also used to confirm any results found through Next Generation Sequencing. Results obtained through this method are >99% accurate.

Where can I get testing?

Talk to your physician about Targeted Mutation Screening and if it right for you. If your physician does not yet offer Viafet testing, please suggest that they contact us - testing can get started immediately. If your physician is already offering Viafet testing, all coordination for your case will be completed between your medical center and Viafet's team.

If at any time during your journey you have questions or would like to speak with a Genetic Counselor, contact Viafet and we will schedule an appointment immediately.