Genetic Testing of Products of Conception following Pregnancy Loss

Foetal loss is the most common pregnancy complication, occurring in 25-30% of recognised pregnancies. More than half of all first trimester pregnancy losses are caused by aneuploidy , missing or additional chromosomes , in the developing foetus. In most cases, aneuploid naturally occurs during early embryo development and is not necessarily associated with family history of either parent or any actions taken by either parent.

Completing genetic testing in order to perform a chromosomal analysis of the products of conception following a miscarriage may help to identify the cause of pregnancy loss and improve the management of a future pregnancy. With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients.

Is genetic testing following pregnancy loss right for me?

It may be advisable to consider completing 24-chromosome analysis following pregnancy loss in the following cases:

  • Couples who have had 2 or more miscarriages (from natural or assisted conception)
  • Couples who are interested in determining if pregnancy loss was caused by a chromosomal factor

Based on your medical history and personal preference, Viafet advises you to consult with your physician in order to determine if completing chromosomal analysis following pregnancy loss is right for you. For more information or to discuss any questions related to genetic testing, contact Viafet today.

How is testing completed?

Viafet completes chromosomal analysis of products of conception through a method called array-CGH, allowing for 24-chromosome aneuploidy screening. Array-CGH has advantages over other methods in that it does not require the culturing of any cells in the laboratory, allowing for a faster turn-around-time and larger depth of information to be retrieved from the sample. The array-CGH utilized by Viafet combines the used of Single Nucleotide polymorphism (SNP) and oligomers and allows for the further identification of polyploidy (a common cause of spontaneous pregnancy loss caused mainly by molar pregnancy), haploidy , unbalanced chromosomal rearrangements and Maternal Cell Contamination .

Maternal Cell Contamination refers to when the sample provided contains tissues that are of maternal origin rather than the fetus. For this reason, a maternal blood sample will be collected and a DNA test will be performed on both maternal and fetal DNA in order to rule out contamination. Through the method utilized by Viafet, your report will indicate what percentage, if any, of the sample provided belonged to the mother. The rate of a Maternal Cell Contamination result is approximately 20%.

Viafet's testing method may be performed directly on fresh products of conception tissue as well as on samples from which a karyotype cannot be performed, such as formalin-fixed paraffin-embedded (FFPE) product of conception tissues.

What will my report tell me?

Your report will be issued within 7 calendar days and will include any diagnosis of aneuploidy , polyploidy , haploidy and unbalanced chromosomal rearrangements in the products of conception. If any amount of Maternal Cell Contamination was measured in the analysis, it will also be included in the report. In the case that no instances of chromosomal abnormality are found in the products of conception, the pregnancy loss was most likely due to non-genetic origin.

If a chromosomal abnormality is detected in the product of conception, Viafet will provide you with a medical recommendation as to how the same condition can be prevented from reoccurring in the future.

Where can I get testing?

Talk to your physician about Product of Conception Chromosomal Analysis and if it right for you. If your physician does not yet offer Viafet testing, please suggest that they contact us - testing can get started immediately. If your physician is already offering Viafet testing, all coordination for your case will be completed between your medical centre and Viafet's team.

With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients. If at any time during your journey you have questions or would like to speak with a Genetic Counselor, contact Viafet and we will schedule an appointment immediately.