Analysis of Chorionic Villus Sampling (CVS)
Chorionic Villus Sampling (CVS) is an invasive prenatal diagnostic test performed between 9 and 12 weeks of pregnancy. By completing CVS, the fetus may be tested for chromosomal abnormalities, such as Down syndrome, or, if there is an indicative family history, for genetic disease. The sample is collected by passing a needle through the abdominal skin of the mother, through the wall of the uterus (womb) and into the placental tissue. A small sample of placental tissue (chorionic villi) is removed and examined in the genetic laboratory.
Viafet is able to complete 24-chromosome aneuploidy screening, screening for single gene disorders or both through CVS. Turn around time is 7 calendar days, allowing time for you and your physician to review your results and make the best decision for the care of you and your baby. Your report will state if you are at low or high risk of carrying a fetus with chromosomal abnormality due to aneuploidy and or genetic disease, based on the requested test. A low risk test result makes it less likely that a fetus has a chromosomal abnormality or inherited condition but all genetic conditions cannot be ruled out. You may also want to discuss with your physician the option of completing a non-invasive test at 10 weeks of pregnancy. With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients
Is CVS right for me?
Based on committee opinion, CVS is generally recommended in pregnancy in one of the following cases:
- Maternal age of 35 years or older
- After receiving an abnormal prenatal screening test result, such as the first trimester screening, maternal serum testing, or non-invasive prenatal test)
- For women who previously had a child or pregnancy with a chromosomal abnormality or defect
- For women who have a known hereditary condition that may put the child at risk of genetic disease (autosomal dominant X-linked or mitochondrial mutation)
- One parent has an inherited disorder or both parents are known carriers of an inherited disorder
CVS has been performed for many years. However, it is an invasive procedure that poses a slight rise of injury to the fetus and of miscarriage. For this reason, CVS is not performed routinely with each pregnancy. Viafet advises you to make the decision on performing CVS during your pregnancy together with your physician. With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients. If you have questions related to genetic testing, contact Viafet today to schedule a consultation with a genetic counselor.
What will I learn from completing CVS?
Depending on your medical history and needs, genetic analysis of CVS can provide you with information on the chromosomal and/or genetic health of you fetus.
Viafet completes chromosomal analysis of CVS through a technique called array-CGH, allowing for the chromosomal analysis of aneuploidy , additional or missing whole chromosomes , in all 24 chromosomes of the fetus through DNA analysis. Array-CGH has advantages over other methods in that it does not require the culturing of any cells in the laboratory, allowing for a faster turn-around-time and larger depth of information to be retrieved from the sample. Examples of the chromosomal abnormalities that may be detected through this method include:
- Down syndrome (Trisomy 21)
- Edwards syndrome (Trisomy 18)
- Patau syndrome (Trisomy 13)
- Klinefelter syndrome
- Turner syndrome
The gender of the fetus may also be identified. Results are >99% accurate.
Based on the family history of mother and father, any genetic disease with a known mutation may be identified through the genetic analysis of the fetus through CVS. Genetic testing to identify genetic disease through CVS looks at the foetal DNA to identify specific gene mutations in order to diagnose an inherited disease. Some examples of inherited disorders that may be diagnosed through CVS include:
- Cystic fibrosis
- Tay-Sachs disease
- Canavan disease
- Sickle cell anaemia
If requested, it is possible to test the fetus for both chromosomal abnormality due to aneuploidy and inherited disease. The gender may also be identified, if requested. Results are >99% accurate.
If you have any questions with regards to your testing, contact Viafet today to discuss your medical history with a genetic counselor.
Maternal Cell Contamination :
There is a chance that the sample collected during CVS will be of maternal origin rather than of the fetus - this is called Maternal Cell Contamination. For this reason, a maternal blood sample will separately be collected in order to rule out contamination. Through the method utilized by Viafet Genomics Laboratory, your report will indicate what percentage, if any, of the sample provided belonged to the mother.
Where can I get testing?
With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients. If at any time during your journey you have questions or would like to speak with a Genetic Counselor, contact Viafet and we will schedule an appointment immediately.