5-Chromosome Pre-Implantation Genetic Screening (PGS)
Pre-Implantation Genetic Screening (PGS) allows for the screening of embryos during In Vitro Fertilization (IVF) in order to identify chromosome abnormalities caused by aneuploidy . Viafet's Luminescent™ 5-chromosome FISH analysis screens chromosomes 13, 18 and 21, and the sex chromosomes, X and Y, reducing the chances of transferring an embryo with a chromosomal abnormality caused by aneuploidy and allows for the gender of each embryo to be identified. With over 15 years of experience in Reproductive Genetics, during which over 15,000 samples have been tested, Viafet specializes in PGS.
Please note that FISH is not available in Australia.
- Is Luminescent™ right for me?
- How does Luminescent™ work?
- What is Aneuploidy?
- Where can I get testing?
Is Luminescent™ right for me?
5-chromosome embryo screening by Viafet's Luminescent™ is most often recommended for couples with:
- Concern for, or previous pregnancy with, a Trisomy: In cases of a previous pregnancy involving Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18) or Patau syndrome (Trisomy 13) or if the couple is concerned about a pregnancy with a Trisomy.
- Interest in Gender Selection or concern for a sex-linked gender illness.
Based on your medical history and personal preference, Viafet advises you to consult with your physician in order to determine if genetic testing such as 5-chromosome Luminescent™ is right for you. For more information about Luminescent™, to discuss any questions related to genetic testing, or to learn where you may complete an IVF cycle with Viafet testing, contact Viafet today.
How does Luminescent™ work?
Completing genetic testing during your IVF cycle provides a wealth of information about each embryo before being transferred back to your uterus. During an IVF cycle, 5-chromosome Luminescent™ can be performed on day 3, 4 or 5 after Egg Retrieval by removing a single cell or cells from the developing embryo. Results are available 12-hours after receiving the samples. Viafet's fast reporting time allows for embryos to be transferred fresh or frozen, depending on your IVF physician's protocol.
Luminescent™ is performed with the use of fluorescent probes that bind to specific chromosomes . Each fluorescent probe is made of a nucleotide sequence specific to either chromosome 13, 18, 21, X or Y. The probes are placed with the embryo sample and hybridise, or find their match. After hybridisation, a microscope that can see fluorescent images is used to count chromosomes 13, 18, 21, X and Y and identify any missing or additional whole chromosomes. Results obtained through Viafet's FISH analysis are >95% accurate.
What is Aneuploidy?
Aneuploidy, what does it mean and how does it happen?
Aneuploidy and pregnancy
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edward syndrome)
- Trisomy 13 (Patau syndrome)
- Klinefelter syndrome (XXY)
- Turner syndrome (X)
- Triple X syndrome (XXX)
- Jacob syndrome (XXY)
Viafet's Luminescent™ 5-chromosome FISH analysis can detect all of the conditions described above. In some instances, there are not entire additional or missing chromosomes but rather small additions or deletions called duplications and deletions - FISH analysis is unable to detect duplications and deletions.
Where can I get testing?
Talk to your IVF physician about 5-Chromosome PGS and if it right for you. If your physician does not yet offer Viafet testing, please suggest that they contact us - testing can get started immediately. If your physician is already offering Viafet testing, all coordination for your case will be completed between your IVF centre and Viafet's team.
With locations in the United Arab Emirates (Dubai and Abu Dhabi), Australia, the Kingdom of Saudi Arabia, Lebanon and more locations coming soon, Viafet's services are available to a wide network of clinicians and patients. If at any time during your journey you have questions or would like to speak with a Genetic Counselor, contact Viafet and we will schedule an appointment immediately.